Interestingly, we identified a novel LOH and CN loss site on chromosome 1p36.22-p36.21, a region frequently deleted also in glioma and neuroblastoma [20] and harboring potential TSGs, such as IIp45 (invasion inhibitory protein 45), found down-regulated in glioblastomas [21], and DHRS3, a dehydrogenase/reductase enzyme frequently inactivated by deletion in human neuroblastoma cell lines [22] and by promoter methylation in melanoma cell lines [23]. The gene discussed is DHRS3; the disease is neuroblastoma.