However, after adjustment for major cardiovascular disease risk factors, there was a clear inverse relationship between ADAMTS-13 and MI (Table 4, Adjusted II): those in the highest third had about 54% of the risk of those in the first third, whilst an increase of 1 SD (32.6%) in ADAMTS-13 was estimated to lead to a 27% reduction in the odds of MI. The gene discussed is ADAMTS13; the disease is cardiovascular disorder.