Both high expression of the VEGF-C and COX-2 were correlated with the presence of lymph node metastasis (P = 0.010, P = 0.012 respectively, both Chi-Square test) and LVI (P = 0.031, P = 0.016 respectively, both Chi-Square test). This evidence concerns the gene PTGS2 and metastatic malignant neoplasm in the lymph nodes.