PENK and familial pancreatic carcinoma: The action of OGF is tonic, stereospecific, reversible, non-cytotoxic and non-apoptotic inducing, not associated with differentiative, migratory, invasive, or adhesive processes, independent of serum, anchorage-independent, and occurs at physiologically relevant concentrations in a wide variety of pancreatic cancers including poorly- and well-differentiated human cell lines [1-3].