The FAM84B gene at 8q24 also shows overexpression but mainly at earlier stages (P = 0.043 and P = 0.002 for intraepithelial neoplasia and carcinomas, respectively), which suggests that FAM84B could also be a target of 8q24 somatic amplification. Here, LRATD2 is linked to intraepithelial neoplasia.