CDH1 and neoplasm: In addition, recent evidence shows that loss of heterozygosity at the KLF6 locus contributes to the transition from the compartmentalized carcinoma to the invasive carcinoma, specifically in sporadic colorectal cancer [66,67], which might suggest a link with the mechanism of tumor-cells compartmentalization in the initial stages of tumorigenesis mediated by E-cadherin [61].