Recent evidence has extended the role of KLF6 inactivation to several other neoplastic processes as esophageal carcinomas [52], glioblastomas [53], head and neck squamous cell carcinomas [54], hepatocellular carcinomas [55], non-small cell lung cancer [56], ovarian carcinomas [57] and particularly, with regard to 8q24 risk variants, to colorectal cancer [58]. The gene discussed is KLF6; the disease is carcinoma of esophagus.