There were significantly more children with severe immunosuppression among those diagnosed with TB compared to those without TB (WHO severe CD4 depletion 117/140 versus 94/150, p < 0.0001), and more children with TB were under their expected weight for age (<60% EWA 29/140 versus 14/150; 60–80% EWA 64/140 versus 46/150, p < 0.01 for both). This evidence concerns the gene CD4 and tuberculosis.