THBS1 and neoplasm: The human miR-17/92 cluster composed of 5 miRNAs (miR-17, 18, 19, 20, 92) was found to be related to tumorigenesis and promoted tumor angiogenesis through targeting the anti-angiogenic thrombospondin-1 (Tsp1) by miR-19 or connective tissue growth factor (CTGF) by miR-18 to down-regulate their functions [19,20].