ESR1 and neoplasm: Hence, we examined the effect of high and low pAkt on the following tumor subtypes: (a) luminal A (ER/PR+ and HER2-), (b) luminal B (ER/PR+ and HER2+), (c) ER/PR-/HER2+, and (d) basal-like (triple-negative, ER/PR, and HER2-).