Our data in Table 6 show the levels of pAkt (median pAkt index) in different tumor subtypes: luminal A (ER/PR and HER2-), 13.4; luminal B (ER/PR+ and HER2+), 42.3; ER/PR- and HER2+, 56.3; and basal-like (ER/PR- and HER2-), 35. This evidence concerns the gene ESR1 and neoplasm.