Oligomeric Abeta but not fibrillar Abeta42 decreases specifically phospho-CREB and the BDNF transcripts IV and V in differentiated SH-SY5Y neuroblastoma cells (Garzon & Fahnestock 2007), confirming the data that sublethal doses of Abeta without specifying the aggregation form downregulate BDNF and CREB in cultured cortical neurons (Tong et al.2001b, 2004). This evidence concerns the gene CREB1 and neuroblastoma.