In late brain passage, abundant and large, plaque-like PrP deposits were scattered throughout the brain, predominantly in the cerebral cortex, corpus callosum, several nuclei of the thalamus, optic tract and brain stem, a distribution similar to that seen in vCJD 1–3 brains (Figure 2; Table S1). The gene discussed is PRNP; the disease is variant Creutzfeldt-Jakob disease.