When EMSAs were performed in the presence of anti-p52, c-Rel, Rel-B, p50, and p65 antibodies in tumour extracts from mice treated with CPT-11 or CPT-11 plus AS602868, supershifts were obtained only in the presence of anti-p50 and anti-p65 antibodies (Figure 3C, right panel). This evidence concerns the gene RELA and neoplasm.