Edwards et al (2003) found that the incidence of BRCA2 mutation in early-onset PRCA sufferers (under the age of 55 years) could be as high as 3.0% (Edwards et al, 2003). The average age of our control group was 55.5 years, so we would expect that at most one of these men could have harboured a BRCA2 mutation. This evidence concerns the gene BRCA2 and pure red-cell aplasia.