Several studies showed higher ghrelin levels (Shimizu et al, 2003; Garcia et al, 2005) or higher levels only in subgroups (61% of 18 breast and colorectal cancer patients) (Wolf et al, 2006) in patients with CACS as compared to non-cachetic cancer patients or healthy controls; however, normal (Huang et al, 2007) ghrelin levels were reported as well. This evidence concerns the gene GHRL and cancer.