TGFB1 and Familial prostate cancer: In conclusion, the findings presented in this study suggest that the microenvironment of SV enhances the progression of prostate cancer through a stimulated invasive potential, and that enhanced uPA production in prostate cancer cells induced by TGF-β1, which is abundantly present in seminal plasma, could therefore be one of the most important mechanisms involved in the progression of prostate cancer following SV invasion.