However, Myc-N amplification is a relatively rare event, occurring, as in our series, in about 10% of localised NB patients (Haase et al, 1999; Perez et al, 2000; Henry et al, 2005; Maris, 2005) and is thus inadequate to identify all the patients who will eventually relapse. Here, MYCN is linked to neuroblastoma.