MYC and neuroblastoma: In addition, a large multi-centre European study (Navarro et al, 2006) and several other national studies (Christiansen et al, 1995; Cheung et al, 1997; Ladenstein et al, 2001; Simon et al, 2003; Sano et al, 2006; Spitz et al, 2006) have indicated that stage and Myc-N status were the only independent risk factors for children with localised NB.