INS and amyotrophic lateral sclerosis: These pathways could be clustered into two categories: (i) upstream events of drug addiction including crosstalk among MAPK signaling, insulin signalling, and calcium signalling, which share properties with long-term potentiation; and (ii) downstream effects including regulation of glycolysis metabolism, regulation of the actin cytoskeleton, and apoptosis, which share components with a list of neurodegenerative disorders such as Huntington disease and amyotrophic lateral sclerosis.