Hamamura and coworkers [3] demonstrated that GD3 promoted melanoma cell invasion through activating p130Cas and paxillin; however, invasion of the human keratinocyte-derived SCC12 cell line was suppressed by GM3 ganglioside via inhibition of matrix metalloproteinase-9 activation, disrupting its association with integrin [41]. This evidence concerns the gene BCAR1 and melanoma.