KRT88P and cirrhosis of liver: 1. HBsAg and anti-HBc positive for at least 6 months;2. Anti-HCV and HCV RNA negative;3. Anti-HDV and/or HDAg negative;4. At least 1 sibling or parent HBsAg positive;5. ALT and/or AST levels greater than 2 times upper limits of normal range for testing hospital before or current;6. No clinical evidence of liver cirrhosis;7. Age ≥ 40.