The observations that several genes involved in synthesis of the phagocyte oxidase, such as gp91phox, were down-regulated in DCs upon infection, and the global superoxide production was less in DCs than in Mφs, argue against this, although differential assembly of the enzyme complex at the phagosome membrane may lead to an increased O2− production locally in the mycobacterial vacuole. Here, CYBB is linked to infection.