ERBB2 and neoplasm: Stratification of young women's tumors by independent characteristics, including nodal status, Her2, tumor grade and size, did not reveal a statistically significant difference in prognosis between clusters defined by pathway deregulation (Supplementary Figures S3, S4, S5 and S6), further supporting the conclusion that patterns of oncogenic pathway deregulation seen in young women are independent of clinico-pathologic features.