HTRA1 and age-related macular degeneration: SNP rs11200638 in the promoter of HTRA1 was typed and found to be in extremely high LD (D′ = 0.98; r2 = 0.93) with rs10490924 and with LOC387715 haplotypes, with the risk allele (A; 47.9% of AMD and 19.4% of control chromosomes) closely associated with rs10490924 allele T and LOC387715 haplotype 2 (Table S2).