HTRA1 and age-related macular degeneration: In addition to carrying the rare coding variant of rs10490924, the detrimental haplotype was also very strongly associated with several variants in the untranslated region of LOC387715 and in the promoter of HTRA1, and we cannot at present discriminate between the relative merits of variation in LOC387715 or the HTRA1 promoter as effectors of AMD susceptibility at this locus.