Secondly, in a separate study, various mutations in MYH3 [MIM 160720] encoding embryonic myosin heavy chain have been causally linked to the occurence of the Freeman-Sheldon syndrome [MIM 193700] and the Sheldon-Hall syndrome (alternatively designated type 2B distal arthrogryposis [MIM 601680]). The gene discussed is MYH3; the disease is Freeman-Sheldon syndrome.