TRPV1 and Pain: N-(4-tertiarybutylphenyl)-4-(3-chloropyridin-2-yl)tetrahydropyrazine-1(2H)-carboxamide (BCTC), a member of that new chemical series, was a highly potent TRPV-1 antagonist that effectively reverses the behavioral effects of inflammatory and neuropathic pain in rats [16,17,19] but is poor in metabolic stability, short half-life, aqueous solubility, and in oral bioavailability [18].