F5 and Rare hereditary thrombophilia: The absent lysis in FVL causes thrombophilia by activating Factor X, therefore leading to an increase of the procoagulant potency, because normal Factor V is joined with FVL, that has not been broken down by activated Protein C. Therefore, we tried to reduce the procoagulant activity of normal Factor Va and also of FVL activated by Peptide1–16.