EGFR and non-small cell lung carcinoma: These proteins, including both receptor (EGFR) and non-receptor kinases (e.g., PLCγ and protein kinase C (PKC) [31,32], Raf, mitogen-activated protein kinase kinase (MEK), and ERK [33-35]), have been experimentally or clinically proven to play an important role in NSCLC tumorigenesis.