The importance of NAB corepressors to the regulation of peripheral nerve myelination by Egr2 was recently confirmed by the demonstration that a double knockout of the Nab1/Nab2 genes results in a phenotype very similar to that of the Egr2 knockout: early lethality and peripheral neuropathy resulting from arrested myelination [22]. The gene discussed is EGR2; the disease is peripheral neuropathy.