INS and cardiovascular disorder: Furthermore, the insulin naïve participants had a similar socio-demographic profile and ethnicity compared to subjects who were insulin-treated, but had a shorter disease duration (4.2 years versus 5.3 years, p < 0.001) and less often complications: cardiovascular disease (47% versus 57%, p < 0.05), eye/vision problems (21% versus 36%, p < 0.05) kidney problems (7% versus 11%, n.s.)and loss of feeling in hands or feet (21% versus 40%, P < 0.001).