More importantly, an association between the -455T>C APOC3 promoter polymorphism and MetS was observed following meta-analysis of the six multi-ethnic groups, with female carriers of ≥1 copy of APOC3 -455C found to have a significant ~2-fold increased risk for MetS (carrier OR 1.92, 95% CI 1.44 to 2.57; P < 0.0001), adjusting for age and study group, and male carriers having a significant ~1.5-fold increased risk (carrier OR 1.52, 95% CI 1.10 to 2.09; P = 0.010), resulting in an overall increased risk of ~1.7-fold (carrier OR 1.73, 95% CI 1.40 to 2.14; P < 0.0001). Here, APOC3 is linked to metabolic syndrome.