Multiple oncogenic HPV-type infections are very common among HIV-positive homosexual men and show almost a 100% association with anal squamous cell carcinoma, especially HPV type 16.6 Although it is well established that HIV seropositivity and low CD4 T-cell count are positively associated with the overall prevalence of HPV,6 few data have been reported regarding these associations on an individual HPV type-specific basis. The gene discussed is CD4; the disease is anal squamous cell carcinoma.