CD40LG and primary biliary cholangitis: Recently, usage of ursodeoxycholic acid (UDCA) is a very common treatment for PBC, and it is known that UDCA lowers the serum level of ALP and γ-GTP, especially among the patients of early stage of PBC.14-16 In our results, levels of γ-GTP and IgM were significantly lower in 2004 than in 1999, although the level of ALP did not decrease.