WSX-1–/– MRL/lpr mice developed a disease resembling human MGN with augmented Th2 responses, confirming that the Th1/Th2 cytokine balance is a key to the pathogenesis of differential types of glomerulonephritis.23 In this study, we generated lines of WSX-1 transgenic MRL/lpr mice to further investigate roles of IL27/WSX-1 in the development of autoimmune disorders in MRL/lpr mice. This evidence concerns the gene IL27RA and autoimmune disease.