With regard to induction of immune response, two participants in UPCI 95-033 who received vaccines composed of IL-4-transfected fibroblasts and irradiated autologous glioma cells demonstrated either local (i.e. immune cell infiltrate at the vaccine site) or systemic (i.e. IFN-γ ELISPOT response against EphA2-derived epitope) immune responses. Here, IFNG is linked to central nervous system cancer.