As IL-4 promotes maturation and IL-12 production of DCs, we subsequently developed another trial for patients with newly diagnosed malignant glioma, using TFG-hIL4-Neo-TK-transfected fibroblasts and type-1-promoting DCs [15] loaded with autologous glioma lysate (UPCI 99-111) [16]. Here, IL4 is linked to central nervous system cancer.