Also using episcleral injection of hypertonic saline in rats to induce elevated IOP, Kasmala and colleagues [36] found that another inhibitor of NOS2, L-N(6)-(1-iminoethyl)lysine 5-tetrazole (which has been shown to be protective in the vessel cauterization glaucoma model [33]) did not protect RGCs from death induced by elevated intraocular pressure. This evidence concerns the gene NOS2 and glaucoma.