Compared to control subjects, African American tuberculosis cases had a significantly increased frequency of rare NSPs in TLR1 (OR = 3.32; P = 0.002), TLR6 (OR = 1.85; P = 0.040), and TLR10 (OR = 1.76; P = 0.009) (Table 2). The gene discussed is TLR1; the disease is tuberculosis.