In humans, RvE1 selectively interacts with both the leukotriene B4 receptor (BLT1) and the G-protein coupled receptor ChemR23 expressed on the surface of neutrophils [11] to promote the resolution of dermal inflammation, peritonitis and colitis in murine models of these diseases [10], [12], [13]. The gene discussed is LTB4R; the disease is colitis.