STAT1 and Huntington disease: In addition, the possible STAT-1 inhibition by HD could disrupt the IFN-gamma signaling pathway resulting in keratinocytes unable to terminate their wound healing state.57 Thus, simultaneous HD-induced NF-kappaB activation and STAT-1 inhibition could alter necrosis, inhibit NO generation, prevent wound healing, and possibly affect vesication and blistering.