INS and metabolic syndrome: WHO-defined subjects were more insulin resistant than subjects without the metabolic syndrome (mean and SD for log HOMA-IR, 0.53 ± 0.14 vs. 0.07 ± 0.23, respectively, p < 0.05) and had higher Framingham risk scores (mean and SD, 2.99 ± 4.64% vs. 1.10 ± 1.87%, respectively, p < 0.05).