SHBG and osteoporosis: On the other hand, overweight (body mass index [BMI] ≥ 27) has been reported as a protective factor for osteoporosis [38], which was observed in our study; in this respect, an increase in the amount of biologically available estrogens has been observed, this due to the conversion of androstenedione into estrone in adipose cells, and a decrease in the concentration of sex hormone-binding globulins [39].