AKT1 and T-cell non-Hodgkin lymphoma: Insulin signaling leads to the activation of PI3-kinase and subsequently the activation of acutely transforming retrovirus Akt8 in rodent T cell lymphoma (Akt otherwise known as protein kinase B), which in turn phosphorylates free cytoplasmic GSK3β and GSK3α at serine (Ser) residues 9 and 21, respectively (Saltiel and Kahn 2001; Lizcano and Alessi 2002).