Of 43 down-regulated genes, 32 enhance immune and inflammatory responses or have been implicated in asthma pathogenesis, including 6 cytokine (Il1b, Il4, Il6, Il10, Il13, Tnfa), 4 chemokine (Ccl8, Ccl11, Ccl24, Cxcl10), and 8 asthma-related genes (Arg1, Ear11, Mcpt1, Sprr2a, Chi3l3, Chi3l4, Chia, Slc7a2). This evidence concerns the gene SPRR2A and asthma.