That THF-diols stimulate PLA2 is not surprising, as inhibition of this enzyme is directly correlated with the inhibition of breast (MCF-7, MDA-MD-231 cells) and prostate cancer (PC-3, PC-3M, DU-1245 cells) cell proliferation in vitro or in vivo when grown as xenografts in nude mice (de Souza et al. 1997; Jaattela et al. 1995). This evidence concerns the gene PLA2G2A and Familial prostate cancer.