This is not surprising in view of the fact that in MCF-7, MCF-10, and MDA-MD-231 breast cancer cells, LOX, but not COX inhibitors, blocked EGF/transforming growth factor-α stimulation of 12-HODE and 13-HODE production and cellular proliferation (Natarajan et al. 1997; Reddy et al. 1997). This evidence concerns the gene EGF and breast cancer.