In EHCC, EGFR expression was significantly associated with macroscopic type (0% in the polypoid type, 24.0% in the non-polypoid type; P=0.0120), lymph node metastasis (P=0.0006), UICC Stage (P=0.0424), lymphatic vessels invasion (P=0.0371), and perineural invasion (P=0.0459). The gene discussed is EGFR; the disease is metastatic malignant neoplasm in the lymph nodes.