EGFR and non-small cell lung carcinoma: The clinical effect of EGFR-TKI in a proportion of patients with NSCLC is associated with several molecular alterations, including EGFR mutations and increased copy number of the EGFR gene, although the relative importance of the alterations remains controversial (Cappuzzo et al, 2006; Dziadziuszko et al, 2006; Riely et al, 2006).