Genes reported to be epigenetically inactivated by hypermethylation in bladder cancer include p16INK4a, CDKN2A, RUNX3 or RASSF1, among others (Cordon-Cardo et al, 2000; Muto et al, 2000; Lee et al, 2001; Markl et al, 2001; Stoehr et al, 2004; Catto et al, 2005; Chapman et al, 2005; Kim et al, 2005; Marsit et al, 2005; Wolff et al, 2005; Urakami et al, 2006). The gene discussed is CDKN2A; the disease is urinary bladder cancer.