Moreover, the population of Foxp3+ cells in stage IV was significantly larger than those in stage I. However, the prevalence of Foxp3+ cells is not significantly associated with the overall survival of patients with gastric cancer, in contrast with previous reports on ovarian carcinoma (Wolf et al, 2005) and pancreatic cancer (Hiraoka et al, 2006). This evidence concerns the gene FOXP3 and familial pancreatic carcinoma.