EIF2AK2 and neoplasm: In mice bearing the MAC16 tumour, which show a similar elevation of phospho PKR in skeletal muscle with weight loss (Eley and Tisdale, 2007), treatment with a PKR inhibitor, at a concentration which reduced levels of phospho PKR down to that found in non tumour-bearing animals, effectively attenuated the depression of body weight, through an increase in lean body mass (Eley et al, 2007).