Earlier reports suggested that periostin expression level was correlated with tumor aggressiveness and/or poorer survival in NSCLC [14,16], SCLC [17], neuroblastoma [15], colon cancers [6], thyroid carcinomas [11], oral squamous cell carcinoma [12] and pancreatic cancer [10]. The gene discussed is POSTN; the disease is malignant colon neoplasm.