COL6A3 encodes a fibrillar protein of the extracellular matrix believed to be involved in cell anchoring and signaling through interactions with integrins [24] and induced by TGF-β1 in dermal fibroblasts [25], suggesting that COL6A3 is a good genetic marker for melanoma-associated stromal fibroblasts. Here, TGFB1 is linked to melanoma.