While knockdown of zebrafish Mtp recapitulates many of the phenotypes of severe, lethal abetalipoproteinemia seen in Mtp−/− mice, including death by failure to transport neutral lipids across the yolk cell layer, an intermediate phenotype of decreased, but not absent, vascular lipid staining was not seen in Mtp MO-injected zebrafish larvae. Here, MTTP is linked to abetalipoproteinemia.