EDN1 and Sepsis: Endothelin-1 (ET-1) and adrenomedullin (ADM), two endothelium-derived vasoactive peptides, have attracted interest as physiological key mediators in vascular tone regulation in sepsis and cardiovascular disease (Levin 1995; Hinson et al. 2000; Landry et al. 2004; Christ-Crain et al. 2005).