Instead of random screening, we decided to use a rationalized approach based on our expression profiling analysis of HCT-116 (wt-p53) and HCT-116 (null-p53) colon cancer cell lines (Xi et al. 2006) to further evaluate the in vivo significance of deregulated miRNAs in relation to chemosensitivity. The gene discussed is TP53; the disease is colonic neoplasm.